87978797威尼斯老品牌(中国)官方网站

结构生物学与细胞信号传导研究组

课题组长

姓名：

许文青教授研究员博士生导师, PhD, 教授

职务：

主任，国家蛋白质科学上海设施

所在院所：

87978797威尼斯老品牌

荣誉称号：

教育经历：

1980—1985，中国科学技术大学，学士
1985—1988，中国科学院生物物理研究所，硕士
1991—1995，美国麻省理工学院（MIT），博士

博士后及工作经历：

1995—1998，美国哈佛大学，博士后
1999/03—2004/06，美国华盛顿大学，助理教授 (TENURE-TRACK)
2004/07—2009/06，美国华盛顿大学，副教授（TENURED）
2009/07—2019/08，美国华盛顿大学，正教授（TENURED）
2019/08—至今，87978797威尼斯老品牌，87978797威尼斯老品牌，正教授（TENURED）

课题组简介

研究方向：

结构生物学与细胞信号传导

研究内容：

（1）Wnt信号通路的分子机制，从Wnt蛋白的合成分泌，细胞表面受体结合，穿膜信号传导，b-catenin 在细胞质内的降解，到细胞核内的Wnt enhanceosome的抑制和激活;

（2）重要癌症治疗新靶点的分子机制与结构研究；

（3）蛋白质修饰酶的结构功能关系研究；

（4）蛋白质设计与蛋白质工程。

课题组网站：

研究成果展示

代表性论文（*第一作者，#通讯作者）

1.Ma, Dan*; Wang, Zhizhi; Merrikh, Christopher N.; Lang, Kevin S.; Lu, Peilong; Li, Xin; Merrikh, Houra; Rao, Zihe; Xu, Wenqing^#.Crystal structure of a membrane-bound O-acyltransferase.NATURE. 11 Oct 2018. 562(7726):286-+.
2.DaRosa, Paul A.*; Wang, Zhizhi; Jiang, Xiaomo; Pruneda, Jonathan N.; Cong, Feng; Klevit, Rachel E.^#; Xu, Wenqing^#.Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.NATURE. 2015. 517(7533):223-U275.
3.Cho, Uhn Soo*; Xu, Wenqing^#.Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme.NATURE. 2007. 445(7123):53-57.
4.Graham, TA*; Weaver, C; Mao, F; Kimelman, D; Xu, WQ^#.Crystal structure of a beta-catenin/Tcf complex.CELL. 2000. 103(6):885-896.
5.Lu, Peilong*; Min, Duyoung; DiMaio, Frank; Wei, Kathy Y.; Vahey, Michael D.; Boyken, Scott E.; Chen, Zibo; Fallas, Jorge A.; Ueda, George; Sheffler, William; Mulligan, Vikram Khipple; Xu, Wenqing; Bowie, James U.; Baker, David^#.Accurate computational design of multipass transmembrane proteins.SCIENCE. 2018. 359(6379):1042-1046.
6.Wang, Hongyang*; Kim, Juhyun; Wang, Zhizhi; Yan, Xiao-Xue; Dean, Ann^#; Xu, Wenqing^#.Crystal structure of human LDB1 in complex with SSBP2.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020. 117(2):1042-1048.
7.Shen, Guobo*; Ke, Jiyuan; Wang, Zhizhi; Cheng, Zhihong; Gu, Xin; Wei, Yuquan; Melcher, Karsten; Xu, H. Eric^#; Xu, Wenqing^#.Structural basis of the Norrin-Frizzled 4 interaction.CELL RESEARCH. 2015. 25(9):1078-1081.
8.Sun, Wei*; Zhu, Ye Julia; Wang, Zhizhi; Zhong, Qiang; Gao, Feng; Lou, Jizhong; Gong, Weimin^#; Xu, Wenqing^#.Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations.NATURE COMMUNICATIONS. 2013. 4.
9.Wang, Zhizhi*; Michaud, Gregory A.; Cheng, Zhihong; Zhang, Yue; Hinds, Thomas R.; Fan, Erkang; Cong, Feng; Xu, Wenqing^#.Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly (ADP-ribosyl)ation-dependent ubiquitination.GENES & DEVELOPMENT. 2012. 26(3):235-240.
10.Morrone, Seamus*; Cheng, Zhihong; Moon, Randall T.; Cong, Feng; Xu, Wenqing^#.Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012. 109(5):1500-1505.
11.Cheng, Zhihong*; Biechele, Travis; Wei, Zhiyi; Morrone, Seamus; Moon, Randall T.; Wang, Liguo; Xu, Wenqing^#.Crystal structures of the extracellular domain of LRP6 and its complex with DKK1.NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2011. 18(11):1204.
12.Xu, Zheng*; Cetin, Bulent; Anger, Martin; Cho, Uhn Soo; Helmhart, Wolfgang; Nasmyth, Kim^#; Xu, Wenqing^#.Structure and Function of the PP2A-Shugoshin Interaction.MOLECULAR CELL. 2009. 35(4):426-441.
13.Liu, Jing*; Phillips, Bryan T.; Amaya, Maria F.; Kimble, Judith^#; Xu, Wenqing^#.The C. elegans SYS-1 protein is a bona fide beta-catenin.DEVELOPMENTAL CELL. 2008. 14(5):751-761.
14.Cho, Uhn Soo*; Morrone, Seamus; Sablina, Anna A.; Arroyo, Jason D.; Hahn, William C.; Xu, Wenqing^#.Structural basis of PP2A inhibition by small t antigen.PLOS BIOLOGY. 2007. 5(8):1810-1819.
15.Sampietro, James*; Dahlberg, Caroline L.; Cho, Uhn Soo; Hinds, Thomas R.; Kimelman, David; Xu, Wenqing^#.Crystal structure of a beta-catenin/BCL9/Tcf4 complex.MOLECULAR CELL. 2006. 24(2):293-300.
16.Xing, Y*; Clements, WK; Le Trong, I; Hinds, TR; Stenkamp, R; Kimelman, D; Xu, WQ^#.Crystal structure of a beta-Catenin/APC complex reveals a critical role for APC phosphorylation in APC function.MOLECULAR CELL. 2004. 15(4):523-533.
17.Xing, Y*; Clements, WK; Kimelman, D; Xu, WQ^#.Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex.GENES & DEVELOPMENT. 2003. 17(22):2753-2764.
18.Graham, TA*; Clements, WK; Kimelman, D; Xu, WQ^#.The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT.MOLECULAR CELL. 2002. 10(3):563-571.
19.Xu, WQ*; Harrison, SC; Eck, MJ.Three-dimensional structure of the tyrosine kinase c-Src.NATURE. 1997. 385(6617):595-602.
20.Xu, Wenqing^#*; Rould, Mark A; Jun, Susie; Desplan, Claude; Pabo, Carl O.CRYSTAL-STRUCTURE OF A PAIRED DOMAIN-DNA COMPLEX AT 2.5-ANGSTROM RESOLUTION REVEALS STRUCTURAL BASIS FOR PAX DEVELOPMENTAL MUTATIONS.CELL. 1995. 80(4):639-650.